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This work aimed to assess the biomechanics, using the finite element method (FEM), of traditional titanium Morse taper (MT) dental implants compared to one‐piece implants composed of zirconia, polyetheretherketone (PEEK), carbon fiber‐reinforced PEEK (CFR‐PEEK), or glass fiber‐reinforced PEEK (GFR‐PEEK). MT and one‐piece dental implants were modeled within a mandibular bone section and loaded on an...
Glass and bioactive glass–ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass–ceramics of the LZS (Li2O‐ZrO2‐SiO2) system are very interesting because of their mechanical, electrical, and thermal properties. Very recently, their biological response in contact with...
Zinc is emerging as a promising biodegradable metal for temporary implant applications. In this work, we investigate the influence of bovine serum albumin (BSA)—the most abundant blood protein in simulated body fluid (SBF) on degradation of pure Zn via electrochemical measurements and long‐term immersion. Electrochemical experiments indicate a decrease of the corrosion rate of bare Zn with increasing...
The cellular response to surfaces is mediated, among other factors, by the extracellular matrix (ECM). However, little is known about the ECM proteome during mineralization. Our objective was to compare the ECM composition formed by osteoblast on different materials surfaces with proteomic analysis. Three types of biomaterial surfaces (pure titanium, anodized titanium, and zirconia) were used. Osteoblasts...
Enamel, once formed, loses the ability to regenerate due to the loss of the formative ameloblasts. It is subjected to constant damaging events due to exposure to external agents and oral microbiomes. An enamel remineralization process targets to replenish the lost ionic component of the enamel through a multitude of methods. Enamel remineralization is highly challenging as it has a complex organized...
Periodontitis would cause dental tissue damage locally. Biomaterials substantially affect the surrounding immune microenvironment through treatment‐oriented local inflammatory remodeling in dental periodontitis. This remodeling process is conducive to wound healing and periodontal tissue regeneration. Recent progress in understanding the foreign body response (FBR) and immune regulation, including...
Regeneration and recovery of nerve tissues are a great challenge for medicine, and positively affect the quality of life of patients. The development of tissue engineering offers a new approach to the problem with the creation of multifunctional artificial scaffolds that act on various levels in the damaged tissue, providing physical and biochemical support for the growth of nerve cells. In this study,...
Iron (Fe) and Fe‐based scaffolds have become a research frontier in absorbable materials which is inherent to their promising mechanical properties including fatigue strength and ductility. Nevertheless, their slow corrosion rate and low biocompatibility have been their major obstacles to be applied in clinical applications. Over the last decade, various modifications on porous Fe‐based scaffolds...
Bio‐mimicked GTR/GBR membranes with hierarchical structured surfaces were developed by direct and indirect replication of teak leaf surface. The membranes were fabricated using solvent casting method with customized templates. The surfaces obtained were those with micro‐trichomes (MTS) and micro‐depression (MDS) that resembled a whorling pattern. Structural details of the fabricated membrane surfaces...
Corrosion and wear are commonly found at the taper‐trunnion connection of modular total hip arthroplasty (THA) explanted devices. While metal/metal (M/M) modular taper‐trunnion connections exhibit more wear/corrosion than ceramic/metal (C/M) modular taper‐trunnion connections, damage is present in both, regardless of material. This study used a combination of assessment techniques including clinical...
Biosafety of AZ31B magnesium (Mg) alloy and the effect of its degradation products on tissues, organs, and whole systems are highly needed to be evaluated before clinical application. This study serves a wide variety of safety evaluations of biodegradable AZ31B alloy on nerve cells. As a result of this in vitro study, the maximum aluminum (Al) ion and Mg ion concentrations in the medium were estimated...
Carbon dots (CDs) are nanomaterials with excellent photoluminescence property, usually used in the field of bioimaging tumor cells. However, its practical applicability in cancer therapeutics is limited by CDs' insensitive surface properties to complicated tumor microenvironment in vivo. Herein, a new type of innovative biomimetic nanoparticles has been formed with HeLa cell membranes (CM) and multifunctional...
Yttria‐stabilized zirconia (YSZ) is being proposed as an alternative material to Titanium for dental implants due to its aesthetic and biocompatibility properties. However, is it yet to define the optimal surface treatment to improve YSZ bioactivy. Texturization is a promising approach, but the biological role of patterned YSZ surfaces in cell cultures is yet to be determined. Thus, cellular behavior...
Biomaterials derived from extracellular matrices (ECMs) were extensively used for skin tissue engineering and wound healing. ECM is a complex network of biomolecules (e.g., proteins), which provide organizational support to cells for growth. Thus, ECM could be an ideal biomaterial for fabricating the scaffold. However, oxidative stress and biofilm formation at the wound site remains a major challenge...
Hypothesis
Injuries requiring resection of tissue followed by autogenous bone transfer may be prone to infection by Staphylococcus aureus, impeding recovery and increasing medical costs. For critical sized defects, the common approach to reconstruction is a tissue transfer procedure but is subject to limitations (e.g., donor site morbidity, cost, operating time). Utilizing beta tricalcium phosphate...
We have studied the charge‐injection characteristics and electrochemical impedance of sputtered ruthenium oxide (RuOx) films as electrode coatings for neural stimulation and recording electrodes. RuOx films were deposited by reactive DC magnetron sputtering, using a combination of water vapor and oxygen gas as reactive plasma constituents. The cathodal charge storage capacity of planar RuOx electrodes...
Measurements of wear resistance and metal ion release are important for designing bearing couples or interfaces in total hip arthroplasty (THA). In this study, we investigated wear resistance and metal ion release of surface‐modified metal‐free all‐polymer hip bearings, such as poly(ether‐ether‐ketone), (PEEK) on cross‐linked polyethylene (PEEK‐on‐CLPE), with a hydrated gel‐like surface layer, to...
The aim of the present systematic review was to analyse studies using inorganic implant coatings and, in a meta‐analysis, the effect of specifically tricalcium phosphate (TCP) and hydroxyapatite (HA) implant surface coatings on bone formation according to the PRISMA criteria. Inclusion criteria were the comparison to rough surfaced titanium implants in large animal studies at different time points...
Surgical site infections (SSIs) are a persistent clinical challenge. Local antimicrobial delivery may reduce the risk of SSI by increasing drug concentrations and distribution in vulnerable surgical sites compared to what is achieved using systemic antimicrobial prophylaxis alone. In this work, we describe a comprehensive in vivo evaluation of the safety and efficacy of poly(N‐isopropylacrylamide‐...
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